COL2A1 Monoclonal Antibody
| 规格： | / 20μL / 60μL / 120μL |
| 价格： | / ￥580 / ￥1420 / ￥2310 |
货号：E-AB-22274
宿主: Mouse
反应性: H,M,R
应用: IHC-p
Overview
| Synonyms | Alpha 1 type II collagen,Alpha-1 type II collagen,AOM,Cartilage collagen,Chondrocalcin,CO2A1,COL11A3,Col2a1,Collagen II alpha 1 polypeptide,SEDC,Collagen II Mouse (1H1)抗体 |
| Swissprot | P02458 |
| Source | Mouse |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic Peptide of Collagen II |
| Application | IHC-p(Detection kit: E-IR-R213) |
| Recommended dilution | IHC 1:50-300 |
| Concentration | 1mg/mL |
| Clonality | Monoclonal |
Properties
| Cellular localization | Secreted>extracellular space>extracellular matrix. |
| Tissue specificity | Isoform 2 is highly expressed in juvenile chondrocyte and low in fetal chondrocyte. |
| Clone No | Clone:1H1 |
|---|---|
| Isotype | IgG |
| Purification | Protein A purification |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.4. |
| Background | This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts identified for this gene. |
