COMT Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-18624
宿主: Rabbit
反应性: H
应用: WB,IHC
Overview
| Synonyms | Catechol O methyltransferase,Catechol O-methyltransferase,COMT,COMT,EC 2.1.1.6,COMT抗体 |
| Swissprot | P21964 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Fusion protein of human COMT |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:2000;IHC,,1:25-1:100; |
| Concentration | 1.02mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm and Cell membrane. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. |
Images
Western blot analysis of Hela cell lysate using COMT Polyclonal Antibody at dilution of 1:450
Immunohistochemistry of paraffin-embedded Human liver cancer tissue using COMT Polyclonal Antibody at dilution of 1:30(×200)
Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using COMT Polyclonal Antibody at dilution of 1:30(×200)
