cPLA2 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-11099
宿主: Rabbit
反应性: H,M,R
应用: WB,IHC,ELISA
Overview
| Synonyms | PLA2G4,cPLA2-alpha,PLA2G4A抗体 |
| Swissprot | P47712 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant protein of human PLA2G4A |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213),ELISA |
| Recommended dilution | WB 1:500-1:2000, IHC 1:50-1:200 |
| Concentration | 0.4 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytosol,Endoplasmic reticulum,endoplasmic reticulum membrane,Golgi apparatus,Golgi apparatus,Mitochondrion,mitochondrial inner membrane,Other locations:cytoplasmic vesicle,lipid droplet |
| Tissue specificity | Expressed in various tissues such as macrophages, platelets, neutrophils, fibroblasts and lung endothelium. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. |
Images
Western Blot analysis of 293T cell using cPLA2 Polyclonal Antibody at dilution of 1:750
Immunohistochemistry of paraffin-embedded Human thyroid cancer using cPLA2 Polyclonal Antibody at dilution of 1:50
Immunohistochemistry of paraffin-embedded Human brain using cPLA2 Polyclonal Antibody at dilution of 1:50
