CRACR2A Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-19269
宿主: Rabbit
反应性: H
应用: IHC
Overview
| Synonyms | Calcium release-activated calcium channel regulator 2A,CRAC channel regulator 2A,CRACR2A,EF hand calcium binding domain 4B,EF hand calcium binding domain containing protein 4B,EF-hand calcium-binding domain-containing protein 4B,EFC4B,EFCAB 4B,Efcab4b,FLJ33805,MGC4266,CRACR2A抗体 |
| Swissprot | Q9BSW2 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Fusion protein of human CRACR2A |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:200 |
| Concentration | 0.84mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | Ca2+-binding protein that plays a key role in store-operated Ca2+ entry (SOCE) in T-cells by regulating CRAC channel activation.Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca2+concentration.It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1.Upon increase of cytoplasmic Ca2+resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex. |
