CRELD2 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-11103
宿主: Rabbit
反应性: H
应用: WB,IHC
Overview
| Synonyms | CREL2,CRELD 2,CRELD2,Cysteine rich with EGF like domain protein 2,Cysteine rich with EGF like domains 2,Cysteine-rich with EGF-like domain protein 2,DKFZp667O055,MGC11256,CRELD2抗体 |
| Swissprot | Q6UXH1 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Recombinant protein of human CRELD2 |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:2000;IHC,,1:50-1:200; |
| Concentration | 0.3 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Secreted. Endoplasmic reticulum. |
| Tissue specificity | Ubiquitously expressed. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | The epidermal growth factor (EGF) repeat-containing proteins constitute an expanding family of proteins that are involved in several cellular activities, such as blood coagulation, fibrinolysis, cell adhesion and neural and vertebrate development.CRELD2 (cysteine-rich with EGF-like domains 2) is a 353 amino acid protein that is ubiquitously expressed and contains two FU domains and two EGF-like domains.Localized to the endoplasmic reticulum and secreted into the cell, CRELD2 interacts with AChR 4, possibly regulating its transport.Human CRELD2 shares 69% amino acid identity with its mouse counterpart, suggesting a conserved role between species.Multiple isoforms of CRELD2 exist due to alternative splicing events.The gene encoding CRELD2 maps to human chromosome 22, which houses over 500 genes and is the second smallest human chromosome.Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, Neurofibromatosis type 2, autism and schizophrenia. |
Images
Western Blot analysis of Human normal colon tissue using CRELD2 Polyclonal Antibody at dilution of 1:550
Immunohistochemistry of paraffin-embedded Human thyroid cancer using CRELD2 Polyclonal Antibody at dilution of 1:50
Immunohistochemistry of paraffin-embedded Human gastric cancer using CRELD2 Polyclonal Antibody at dilution of 1:50
