CRK Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-14896
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
| Synonyms | Adapter molecule crk,Avian sarcoma virus CT10 (v crk) oncogene homolog,CRK,CRK isoform 2,CRK isoform II,CRK,CRKII,FLJ38130,OTTHUMP00000115366,OTTHUMP00000198330,p38,Proto oncogene C crk,Proto-oncogene C-crk,v crk avian sarcoma virus CT10 oncogene homolog,v crk sarcoma virus CT10 oncogene homolog,v crk sarcoma virus CT10 oncogene homolog (avian),CRK抗体 |
| Swissprot | P46108 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant protein of human CRK |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:200 |
| Concentration | 0.4 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. Cell membrane. Translocated to the plasma membrane upon cell adhesion. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. |
