CRMP1 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-12333
宿主: Rabbit
反应性: H,M,R
应用: WB,IHC
Overview
| Synonyms | Collapsin response mediator protein 1,CRMP 1,CRMP-1,Crmp1,Dihydropyrimidinase like 1,Dihydropyrimidinase related protein 1,Dihydropyrimidinase-related protein 1,DPYL1,DPYSL1,DRP 1,DRP-1,DRP1,ULIP-3,Ulip3,Unc-33-like phosphoprotein 3,CRMP1抗体 |
| Swissprot | Q14194 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic peptide of human CRMP1 |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:1000; |
| Concentration | 0.4 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. Cytoplasm>cytoskeleton>centrosome. Cytoplasm>cytoskeleton>spindle. Associated with centrosomes and the mitotic spindle during metaphase. |
| Tissue specificity | Brain. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | Collapsin response mediator protein 1, encoded by the CRMP1 gene, is a human protein of the CRMP family.This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system.The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development.Alternative splicing results in multiple transcript variants.CRMP1 mediates reelin signaling in cortical neuronal migration.Mice deficient in CRMP1 exhibit impaired long-term potentiation and impaired spatial learning and memory.CRMP1 gene overlaps with another gene called EVC.CRMP1 has been shown to interact with DPYSL2. |
