Crystallin-alpha C Monoclonal Antibody
| 规格： | / 20μL / 60μL / 120μL |
| 价格： | / ￥580 / ￥1420 / ￥2310 |
货号：E-AB-22177
宿主: Mouse
反应性: H,M,R
应用: WB
Overview
| Synonyms | Alpha crystallin C chain,Alpha-crystallin C chain,Charcot Marie Tooth disease axonal type 2L,Charcot Marie Tooth disease spinal,CMT2L,CRYAC,DHMN 2,DHMN2,E2 induced gene 1 protein,E2-induced gene 1 protein,E2IG1,H11,Heat shock 22kDa protein 8,Heat shock 27kDa protein 8,Heat shock protein 22,Heat shock protein beta 8,Heat shock protein beta-8,Hereditary motor neuropathy distal,HMN 2,HMN2,HMN2A,HSB8,HSPB 8,Hspb8,HSPB8,OTTHUMP00000239768,Protein kinase H11,Small stress protein like protein HSP22,Small stress protein-like protein HSP22,Spinal muscular atrophy distal adult autosomal dominant,HSPB8/HSP22抗体 |
| Swissprot | Q9UJY1 |
| Source | Mouse |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant Protein |
| Application | WB(Detection kit: E-IR-R304) |
| Recommended dilution | WB,,1:1000-2000; |
| Concentration | 1mg/mL |
| Clonality | Monoclonal |
Properties
| Cellular localization | Cytoplasm. Nucleus. Translocates to nuclear foci during heat shock. |
| Tissue specificity | Predominantly expressed in skeletal muscle and heart. |
| Isotype | IgG |
| Purification | Protein A purification |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4. |
| Background | The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease. |
