CXCL9/MIG Polyclonal Antibody(Capture/Detector)
| 规格： | / 25μg / 100μg |
| 价格： | / 询价 / 询价 |
货号：AN003890P
货期：咨询
宿主: Rabbit
反应性: H
应用: ELISA Capture/Detector
Overview
| Synonyms | crg;CXCL;SCYB;C-X-C Motif Chemokine;Small-Inducible Cytokine B;Chemokine(C-X-C motif) ligand;CXCL9;CMK;Humig;MIG;SCYB9;crg-10;Chemokine(C-X-C motif) ligand 9;C-X-C Motif Chemokine 9;Gamma-Interferon-Induced Monokine;Monokine induced by gamma interferon;Monokine Induced by Interferon-Gamma;Monokine Induced by Interferon-γ;Small-Inducible Cytokine B9 |
| Swissprot | Q07325 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Recombinant Human CXCL9/MIG Protein expressed by E.coli |
| Application | ELISA Capture/Detector |
| Recommended dilution | ELISA Capture,,2-8 μg/mL;ELISA Detector,,0.1-0.4 μg/mL |
| Concentration | 1mg/mL |
| Clonality | Polyclonal |
Properties
| Isotype | IgG |
| Purification | Antigen Affinity Purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions. |
| Storage buffer | Sterile PBS ,pH 7.4 |
| Background | C-X-C motif chemokine ligand 9 (CXCL9, MIG) is a soluble chemokine expressed by multiple cell types, such as endothelial cells, monocytes, and tumor cells. The expression of CXCL9 is upregulated in response to proinflammatory cytokines, such as IFN-γ and TNF-α. (1,2). CXCL9 binds to CXCR3, a GPCR that is expressed on the surface of multiple populations of immune cells, particularly exclusively activated T lymphocytes (3). Binding of CXCL9 to CXCR3 promotes T cell chemotaxis and infiltration into sites of inflammation that form in settings such as viral infection and tumorigenesis (4-6). Research studies have demonstrated production of CXCL9 by tumor cells mediates tumor suppression through the recruitment of tumor antigen-specific T cells (7). |
