CXCR4 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-11047
宿主: Rabbit
反应性: H
应用: IHC
Overview
| Synonyms | C-X-C chemokine receptor type 4,CD184,CD184 antigen,Chemokine (C X C motif) receptor 4,Chemokine CXC Motif Receptor 4,CXC-R4,CXCR-4,CXCR4,CXCR4,D2S201E,FB22,Fusin,HM89,HSY3RR,LAP 3,LAP3,LCR1,LESTR,Leukocyte derived seven transmembrane domain receptor,Leukocyte-derived seven transmembrane domain receptor,Lipopolysaccharide associated protein 3,Neuropeptide Y receptor Y3,NPY3R,NPYR,NPYRL,NPYY3,NPYY3R,Probable G protein coupled receptor lcr1 homolog,SDF 1 receptor,SDF-1 receptor,SEVEN-TRANSMEMBRANE-SEGMENT RECEPTOR,Stromal cell derived factor 1 receptor,Stromal cell-derived factor 1 receptor,WHIM,WHIMS,CXCR4抗体 |
| Swissprot | P61073 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Recombinant protein of human CXCR4 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:200 |
| Concentration | 0.5 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cell membrane. In unstimulated cells, diffuse pattern on plasma membrane. On agonist stimulation, colocalizes with ITCH at the plasma membrane where it becomes ubiquitinated. |
| Tissue specificity | Expressed in numerous tissues, such as peripheral blood leukocytes, spleen, thymus, spinal cord, heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, cerebellum, cerebral cortex and medulla (in microglia as well as in astrocytes), brain microvascular, coronary artery and umbilical cord endothelial cells. Isoform 1 is predominant in all tissues tested. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1.The protein has 7 transmembrane regions and is located on the cell surface.It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells.Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome.Alternate transcriptional splice variants, encoding different isoforms, have been characterized. |
