CXCR7 Polyclonal Antibody
| 规格： | / 60μL / 120μL / 200μL |
| 价格： | / ￥1380 / ￥2220 / ￥3300 |
货号：E-AB-70115
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
| Synonyms | ACKR3,atypical chemokine receptor 3,C X C chemokine receptor type 7,C-X-C chemokine receptor type 7,Chemokine (C-X-C motif) receptor 7,Chemokine C X C motif receptor 7,Chemokine orphan receptor 1,CMKOR1,CXC R7,CXC-R7,CXCR 7,CXCR-7,CXCR7,CXCR7,G protein coupled receptor 159,G protein coupled receptor,G protein coupled receptor RDC1 homolog,G-protein coupled receptor 159,G-protein coupled receptor RDC1 homolog,GPR159,GPRN1,RDC 1,RDC-1,RDC1,CXCR7抗体 |
| Swissprot | P25106,P56485,O89039 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse CXCR7 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:100-1:200 |
| Concentration | 130 μg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cell membrane. |
| Tissue specificity | Expressed in monocytes, basophils, B-cells, umbilical vein endothelial cells (HUVEC) and B-lymphoblastoid cells. Lower expression detected in CD4+ T-lymphocytes and natural killer cells. In the brain, detected in endothelial cells and capillaries, and in mature neurons of the frontal cortex and hippocampus. Expressed in tubular formation in the kidney. Highly expressed in astroglial tumor endothelial, microglial and glioma cells. Expressed at low levels in normal CD34+ progenitor cells, but at very high levels in several myeloid malignant cell lines. Expressed in breast carcinomas but not in normal breast tissue (at protein level).Highest expression level in synovial joint. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
| Background | CXCR7 (C-X-C chemokine receptor type 7),also known as RDC1,is a member of the G-protein coupled receptor family. CXCR7 can bind the chemokines CXCL11 and CXCL12 with high affinity,and it also acts as coreceptor with CXCR4 for a restricted number of HIV isolates. Expression of CXCR7 has been associated with cardiac development as well as with tumor growth and progression. |
Images
Immunohistochemistry analysis of paraffin-embedded human lung using CXCR7 Polyclonal Antibody at dilution of 1:100.
Immunohistochemistry analysis of paraffin-embedded human stomach using CXCR7 Polyclonal Antibody at dilution of 1:100.
Immunohistochemistry analysis of paraffin-embedded mouse kidney using CXCR7 Polyclonal Antibody at dilution of 1:200.
Immunohistochemistry analysis of paraffin-embedded rat kidney using CXCR7 Polyclonal Antibody at dilution of 1:200.
