DCTN3 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-14937
宿主: Rabbit
反应性: H
应用: IHC
Overview
| Synonyms | DCNT22,DCTN 22,DCTN22,Dctn3,DCTN3,dynactin 3 (p22),dynactin 3,dynactin 3 isoform 1,Dynactin complex subunit 22 kDa subunit,dynactin light chain,Dynactin subunit 3,p22,DCTN3抗体 |
| Swissprot | O75935 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Recombinant protein of human DCTN3 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:100-1:300 |
| Concentration | 0.6 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. Cytoplasm>cytoskeleton>centrosome. Chromosome>centromere>kinetochore. Cytoplasm>cytoskeleton>spindle. Cleavage furrow. Midbody. Localizes to punctate cytoplasmic structures and to the centrosome during interphase, and to kinetochores and to spindle poles throughout mitosis. Colocalizes with dynein to the cleavage furrow and to midbody of dividing cells. |
| Tissue specificity | Ubiquitously expressed. Highly expressed in muscle and pancreas and detected at lower levels in brain. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD.Dynactin binds to both microtubules and cytoplasmic dynein.It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis.This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex.It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin.Alternative splicing results in multiple transcript variants. |
