DMRT3 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-11162
宿主: Rabbit
反应性: H,M,R
应用: WB,IHC
Overview
| Synonyms | DMRT 3,DMRT like family A3,dmrt3,DMRT3,DMRTA3,Doublesex and mab 3 related transcription factor 3,Doublesex- and mab-3-related transcription factor 3,MGC142144,Testis specific protein,DMRT3抗体 |
| Swissprot | Q9NQL9 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant protein of human DMRT3 |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:2000; |
| Concentration | 0.4 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Nucleus. |
| Tissue specificity | Specifically expressed in testis. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | The DMRT (doublesex and mab-3 related transcription factor) genes encode a large family of transcription factors that are related to the Drosophila doublesex proteins. Expressed primarily in the gonads, DMRT proteins contain cysteine-rich DNA-binding motifs and are thought to play an important role in sexual development. DMRT3 (doublesex and mab-3 related transcription factor 3), also known as DMRTA3, is a 472 amino acid protein that contains one DM DNA-binding domain and belongs to the DMRT family. Localized to the nucleus, DMRT3 is expressed specifically in testis and is thought to regulate transcriptional events during early sexual development. The gene encoding DMRT3 maps to human chromosome 9, which houses over 900 genes and comprises nearly 4% of the human genome. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, and Familial dysautonomia, are both associated with chromosome 9. Notably, chromosome 9 encompasses the largest interferon family gene cluster. |
Images
Western Blot analysis of Mouse stomach and brain tissue using DMRT3 Polyclonal Antibody at dilution of 1:550
Immunohistochemistry of paraffin-embedded Human gastic cancer using DMRT3 Polyclonal Antibody at dilution of 1:25
Immunohistochemistry of paraffin-embedded Human brain using DMRT3 Polyclonal Antibody at dilution of 1:25
