DOK1 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-10290
宿主: Rabbit
反应性: H,M,R
应用: WB
Overview
| Synonyms | Docking protein 1 62kD,Docking protein 1,DOK 1,DOK1,DOK1,Downstream of tyrosine kinase 1,p62(dok),P62DOK,pp62,DOK1抗体 |
| Swissprot | Q99704 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant protein of human DOK1 |
| Application | WB(Detection kit: E-IR-R304) |
| Recommended dilution | WB,,1:500-1:2000; |
| Concentration | 0.5 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm and Cytoplasm>perinuclear region. |
| Tissue specificity | Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Two transcript variants encoding different isoforms have been found for this gene. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. |
