ELANE Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-17904
宿主: Rabbit
反应性: H
应用: IHC
Overview
| Synonyms | Bone marrow serine protease,ELA2,ELANE,Elastase 2,Elastase 2 neutrophil ,Elastase neutrophil expressed,Elastase-2,ELNE,GE,Granulocyte derived elastase,HLE,HNE,Human leukocyte elastase,Leukocyte elastase,Medullasin,NE,Neutrophil elastase,PMN E,PMN elastase,Polymorphonuclear elastase,SCN1,ELANE抗体 |
| Swissprot | P08246 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Synthetic peptide of human ELANE |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:30-1:150 |
| Concentration | 0.9mg/mL |
| Clonality | Polyclonal |
Properties
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is present in a gene cluster on chromosome 19. |
