EMD Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-11190
宿主: Rabbit
反应性: H
应用: WB
Overview
| Synonyms | EDMD,Emd,EMD,Emerin,Emery Dreifuss muscular dystrophy,STA,EMD抗体 |
| Swissprot | P50402 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Recombinant protein of human EMD |
| Application | WB(Detection kit: E-IR-R304) |
| Recommended dilution | WB,,1:1000-1:5000; |
| Concentration | 0.4 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Nucleus inner membrane. Nucleus outer membrane. Colocalized with BANF1 at the central region of the assembling nuclear rim, near spindle-attachment sites. The accumulation of different intermediates of prelamin-A/C (non-farnesylated or carboxymethylated farnesylated prelamin-A/C) in fibroblasts modify its localization in the nucleus. |
| Tissue specificity | Skeletal muscle, heart, colon, testis, ovary and pancreas. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | Emerin is a serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. It mediates membrane anchorage to the cytoskeleton. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the emerin gene. |
