Endoglin/CD105 Polyclonal Antibody(Capture/Detector)
| 规格： | / 25μg / 100μg |
| 价格： | / ￥800 / ￥2100 |
货号：AN000260P
货期：咨询
宿主: Rabbit
反应性: H
应用: ELISA Capture/Detector
Overview
| Synonyms | ENG;CD105;EndogLin;END |
| Swissprot | P17813 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Recombinant Human Endoglin/CD105 protein expressed by E.coli |
| Application | ELISA Capture/Detector |
| Recommended dilution | ELISA Capture,,2-8 μg/mL;ELISA Detector,,0.1-0.4 μg/mL |
| Concentration | 1mg/mL |
| Clonality | Polyclonal |
Properties
| Isotype | IgG |
| Purification | Antigen Affinity Purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at 4°C Valid for 1 month or -20°C Valid for 12 months,Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions. |
| Storage buffer | Sterile PBS,pH 7.4 |
| Background | Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis.Required for normal structure and integrity of adult vasculature.Regulates the migration of vascular endothelial cells.Required for normal extraembryonic angiogenesis and for embryonic heart development.May regulate endothelial cell shape changes in response to blood flow,which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis.May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors.Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors.Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3. |
