EPOR Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-15623
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
| Synonyms | EPO R,EPO-R,epor,EPOR,Erythropoietin receptor,Erythropoietin receptor precursor,MGC138358,EPOR抗体 |
| Swissprot | P19235 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic peptide of human EPOR |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:200 |
| Concentration | 0.7 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cell membrane and Secreted. Secreted and located to the cell surface. |
| Tissue specificity | Erythroid cells and erythroid progenitor cells. Isoform EPOR-F is the most abundant form in EPO-dependent erythroleukemia cells and in late-stage erythroid progenitors. Isoform EPOR-S and isoform EPOR-T are the predominant forms in bone marrow. Isoform EPOR-T is the most abundant from in early-stage erythroid progenitor cells. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants. |
Images
Immunohistochemistry of paraffin-embedded Human liver cancer tissue using EPOR Polyclonal Antibody at dilution 1:40
Immunohistochemistry of paraffin-embedded Human brain tissue using EPOR Polyclonal Antibody at dilution 1:40
Immunohistochemistry of paraffin-embedded Placenta tissue using EPOR Polyclonal Antibody at dilution of 1:70(Elabscience® Product Detected by Lifespan).
