ER alpha Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-15624
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
| Synonyms | DKFZp686N23123,ER alpha,ER,ER-alpha,Era,ESR,ESR1,ESR1,ESRA,Estradiol receptor,Estrogen nuclear receptor alpha,Estrogen receptor 1,Estrogen receptor alpha 3*,4,5,6,7*/822 isoform,Estrogen receptor alpha,Estrogen receptor alpha delta 3*,4,5,6,7*,8*/941 isoform,Estrogen receptor alpha delta 3*,4,5,6,7*/819 2 isoform,Estrogen receptor alpha delta 4 +49 isoform,Estrogen receptor alpha delta 4*,5,6,7*/654 isoform,Estrogen receptor alpha delta 4*,5,6,7,8*/901 isoform,Estrogen receptor alpha E1 E2 1 2,Estrogen receptor alpha E1 N2 E2 1 2,Estrogen receptor,ESTRR,NR3A1,Nuclear receptor subfamily 3 group A member 1,ESR1抗体 |
| Swissprot | P03372 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic peptide of human ESR1 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:100-1:300 |
| Concentration | 0.6 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Nucleus. Cytoplasm. Cell membrane. A minor fraction is associated with the inner membrane and Nucleus. Cytoplasm. Cell membrane. Associated with the inner membrane via palmitoylation. |
| Tissue specificity | Widely expressed. Isoform 3 is not expressed in the pituitary gland. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters. |
