EWSR1 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-18995
宿主: Rabbit
反应性: H,M
应用: WB,IHC
Overview
| Synonyms | bK984G1.4,bK984G1.4 Ewing sarcoma breakpoint region 1 protein,Ewing sarcoma breakpoint region 1,Ewing sarcoma breakpoint region 1 protein,Ewings sarcoma EWS Fli1 type 1 oncogene,EWS,EWS oncogene,EWS RNA binding protein 1,EWS,EWSR 1,Ewsr1,EWSR1 protein,RNA binding protein EWS,RNA-binding protein EWS,EWSR1抗体 |
| Swissprot | Q01844 |
| Source | Rabbit |
| Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human EWSR1 |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:1000-1:5000;IHC,,1:50-1:300; |
| Concentration | 1.26mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Nucleus. Cytoplasm. Cell membrane. Relocates from cytoplasm to ribosomes upon PTK2B/FAK2 activation. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14. |
Images
Western blot analysis of 293T and HepG2 cell lysates using EWSR1 Polyclonal Antibody at dilution of 1:1000
Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using EWSR1 Polyclonal Antibody at dilution of 1:70(×200)
Immunohistochemistry of paraffin-embedded Human lung cancer tissue using EWSR1 Polyclonal Antibody at dilution of 1:70(×200)
