EZH2 Polyclonal Antibody
| 规格： | / 60μL / 120μL / 200μL |
| 价格： | / ￥1380 / ￥2220 / ￥3300 |
货号：E-AB-70131
宿主: Rabbit
反应性: H,M
应用: WB
Overview
| Synonyms | Enhancer of zeste 2,enhancer of zeste 2 polycomb repressive complex 2 subunit,Enhancer of zeste homolog 2 (Drosophila),Enhancer of zeste homolog 2,Enhancer of zeste,Drosophila,homolog 2,ENX 1,Enx 1h,ENX-1,ENX1,Enx1h,EZH 2,EZH1,EZH2,EZH2,EZH2b,Histone-lysine N-methyltransferase EZH2,KMT 6,KMT6,KMT6A,Lysine N-methyltransferase 6,MGC9169,WVS,WVS2,EZH2抗体 |
| Swissprot | Q15910,Q61188 |
| Source | Rabbit |
| Reactivity | Human,Mouse |
| Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse EZH2 |
| Application | WB(Detection kit: E-IR-R304) |
| Recommended dilution | WB,,1:500-1:2000; |
| Concentration | 0.54 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Nucleus. |
| Tissue specificity | Expressed in many tissues. Overexpressed in numerous tumor types including carcinomas of the breast, colon, larynx, lymphoma and testis.Highest expression level in lung. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
| Background | EZH2 (enhancer of zeste homologue 2,also known as KMT6) is a member of Polycomb group (PcG) family and encodes a histone methyl transferase that has an essential role in promoting histone H3 lysine 27 trimethylation (H3K27me3) and epigenetic gene silencing. EZH2 is important for cell proliferation and inhibition of cell differentiation,and is implicated in cancer progression. Overexpression of EZH2 is a marker of advanced and metastatic disease in many solid tumors,including prostate and breast cancer. This antibody detected EZH2 protein as a single band with a molecular weight (MW) of 91-100 kDa in multiple cell lines. The phosphorylation may result in the higher molecular weight (calculated MW as 80-86 kDa). (20935635,21367748) |
