Factor XIIIa Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-16093
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
| Synonyms | bA525O21.1 (coagulation factor XIII,A1 polypeptide),Coagulation factor XIII A chain,Coagulation factor XIII A1 polypeptide,Coagulation factor XIII A1 subunit,Coagulation factor XIII,A polypeptide,Coagulation factor XIIIa,F13A,F13A,F13a1,Factor XIIIA,Fibrin stabilizing factor,A subunit,Fibrinoligase,FSF,A subunit,Protein glutamine gamma glutamyltransferase A chain,Protein-glutamine gamma-glutamyltransferase A chain,TGase,Transglutaminase A chain,Transglutaminase,plasma,Transglutaminase. plasma,F13A1抗体 |
| Swissprot | P00488 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic peptide of human F13A1 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:100-1:300 |
| Concentration | 0.7 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm, Secreted |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. |
