FADD Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-14078
宿主: Rabbit
反应性: H
应用: IHC
Overview
| Synonyms | FADD,FADD protein,FADD,Fas (TNFRSF6) associated via death domain,Fas associated via death domain,Fas associating death domain containing protein,Fas associating protein,Fas associating protein with death domain,Fas TNFRSF6 associated via death domain,FAS-associated death domain protein,FAS-associating death domain-containing protein,GIG 3,GIG3,Growth inhibiting gene 3 protein,Growth-inhibiting gene 3 protein,H sapiens mRNA for mediator of receptor induced toxicity,Mediator of receptor induced toxicity,MGC8528,MORT 1,MORT1,Protein FADD,FADD抗体 |
| Swissprot | Q13158 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Recombinant protein of human FADD |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:150 |
| Concentration | 0.6 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytosol,ripoptosome,Nucleus,Plasma Membrane,CD95 death-inducing signaling complex,death-inducing signaling complex,plasma membrane,Other locations:cell body,cytoplasm,membrane raft,neuron projection |
| Tissue specificity | Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. |
