FGFR4 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-19391
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
| Synonyms | CD 334,CD334,CD334 antigen,fc13h 10,fc13h10,Fgfr 4,FGFR-4,Fgfr4,FGFR4,Fibroblast growth factor receptor 4,Hydroxyaryl protein kinase,JTK 2,JTK2,MGC20292,Protein tyrosine kinase,TKF,Tyrosine kinase related to fibroblast growth factor receptor,Tyrosylprotein kinase,FGFR4抗体 |
| Swissprot | P22455 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic peptide of human FGFR4 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:10-1:50 |
| Concentration | 0.72mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Membrane. Isoform 2 may be secreted. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. FGFR4 (Fibroblast Growth Factor Receptor 4) is a Protein Coding gene. Diseases associated with FGFR4 include Prostate Cancer and Neuroma. Among its related pathways are GPCR Pathway and RET signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is FGFR3. |
