FGR Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-19870
宿主: Rabbit
反应性: H
应用: IHC
Overview
| Synonyms | c fgr,c fgr protooncogene,c src 2 proto oncogene,c src2,Fgr,FGR,FLJ43153,Gardner Rasheed feline sarcoma viral (v fgr),Gardner Rasheed feline sarcoma viral (v fgr) oncogene homolog,Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog,MGC75096,p55 c fgr protein,P55 FGR,P55-FGR,p55c fgr,p58-Fgr,p58c fgr,p58c-Fgr,Proto oncogene c Fgr,Proto oncogene tyrosine protein kinase FGR,Proto-oncogene c-Fgr,SRC 2,SRC2,Tyrosine protein kinase Fgr,Tyrosine-protein kinase Fgr,FGR抗体 |
| Swissprot | P09769 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Synthetic peptide of human FGR |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:300 |
| Concentration | 2.04mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cell membrane. Cell membrane. Cell projection>ruffle membrane. Cytoplasm>cytosol. Cytoplasm>cytoskeleton. Mitochondrion inner membrane. Mitochondrion intermembrane space. Detected in mitochondrial intermembrane space and at inner membranes (By similarity). Colocalizes with actin fibers at membrane ruffles. Detected at plasma membrane lipid rafts. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. |
