FLT1 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-40333
宿主: Rabbit
反应性: H
应用: IHC
Overview
| Synonyms | EC 2.7.10.1,FLT 1,FLT,Flt-1,FLT1,Fms like tyrosine kinase 1,Fms related tyrosine kinase 1,Fms related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor),Fms related tyrosine kinase 1 vascular endothelial growth factor/vascular permeability factor receptor,Fms-like tyrosine kinase 1,FRT,Soluble VEGF receptor 1 14,Soluble VEGFR1 variant 2,Soluble VEGFR1 variant 21,Tyrosine protein kinase FRT,Tyrosine protein kinase receptor FLT,Tyrosine-protein kinase FRT,Tyrosine-protein kinase receptor FLT,Vascular endothelial growth factor receptor 1,Vascular endothelial growth factor vascular permeability factor receptor,Vascular permeability factor receptor 1,Vascular permeability factor receptor,VEGFR 1,VEGFR-1,VEGFR1,VGFR1,FLT1抗体 |
| Swissprot | P17948 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Recombinant Human Vascular endothelial growth factor receptor 1 protein |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC 1:100-1:400 |
| Concentration | 2mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Secreted and Cell membrane |
| Tissue specificity | Mostly in normal lung, but also in placenta, liver, kidney, heart and brain tissues. Specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. Isoform sFlt1 is strongly expressed in placenta. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% Proclin300, 50% glycerol, pH7.3. |
| Background | This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia. |
