Frataxin/FXN Polyclonal Antibody
| 规格： | / 25μg / 100μg |
| 价格： | / ￥800 / ￥2100 |
货号：AN000510P
货期：咨询
宿主: Rabbit
反应性: H
应用: ELISA Capture/Detector
Overview
| Synonyms | CyaY;d-FXN;FA;FARR;Frataxin mature form;Frataxin(81-210);FRDA;FRDA;Friedreich ataxia protein;Fxn;i-FXN;m56-FXN;m78-FXN;m81-FXN;MGC57199;X25 |
| Swissprot | Q16595 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Recombinant Human Frataxin/FXN protein expressed by E.coli |
| Application | ELISA Capture/Detector |
| Recommended dilution | ELISA Capture,,2-8 μg/mL;ELISA Detector,,0.1-0.4 μg/mL |
| Concentration | 1mg/mL |
| Clonality | Polyclonal |
Properties
| Isotype | IgG |
| Purification | Antigen Affinity Purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at 4°C Valid for 1 month or -20°C Valid for 12 months,Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions. |
| Storage buffer | Sterile PBS,pH 7.4 |
| Background | FXN,also named as FRDA,X25,m81-FXN,d-FXN,m78-FXN and i-FXN,belongs to the frataxin family. It promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe2+ to proteins involved in these pathways. FXN may play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe2+ to Fe3+; the oligomeric form but not the monomeric form has in vitro ferroxidase activity. FXN is cleaved to be 4 chains. FXN is expressed in the cytoplasm as a 210 amino acid (AA) precursor protein (pFXN; 23?KDa) that is translocated into mitochondria where it is processed by two consecutive steps into iFXN (FXN 42-210; 19?KDa) and finally mFXN (81-210; 14.2 KDa),which is functional. |
