FUT3 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-17979
宿主: Rabbit
反应性: H
应用: IHC
Overview
| Synonyms | Alpha-(1,3/1,4)-fucosyltransferase,Blood group Lewis alpha-4-fucosyltransferase,CD174,FT3B,Fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group),Fucosyltransferase 3,Fucosyltransferase III,FucT III,FucT-III,FUT3,FUT3,Galactoside 3(4)-L-fucosyltransferase,LE,Les,Lewis FT,FUT3抗体 |
| Swissprot | P21217 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Synthetic peptide of human FUT3 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:40-1:200 |
| Concentration | 1.08mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Golgi apparatus>Golgi stack membrane. Membrane-bound form in trans cisternae of Golgi. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. |
