GHR Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-17322
宿主: Rabbit
反应性: H,M,R
应用: WB
Overview
| Synonyms | GH receptor,GH-binding protein,GHBP,GHBP,included,GHR,GHR,Growth hormone binding protein,Growth hormone receptor,Growth hormone receptor precursor,Growth hormone-binding protein,Growth hormone-binding protein,included,Increased responsiveness to growth hormone,included,Serum binding protein,Serum-binding protein,Somatotropin receptor,GHR抗体 |
| Swissprot | P10912 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic peptide of human GHR |
| Application | WB(Detection kit: E-IR-R304) |
| Recommended dilution | WB,,1:500-2000; |
| Concentration | 0.3mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Secreted; Cell membrane. On growth hormone binding, GHR is ubiquitinated, internalized, down-regulated and transported into a degradative or non-degradative pathway and Cell membrane. Remains fixed to the cell membrane and is not internalized. |
| Tissue specificity | Expressed in various tissues with high expression in liver and skeletal muscle. Isoform 4 is predominantly expressed in kidney, bladder, adrenal gland and brain stem. Isoform 1 expression in placenta is predominant in chorion and decidua. Isoform 4 is highly expressed in placental villi. Isoform 2 is expressed in lung, stomach and muscle. Low levels in liver. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone.Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth.Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. |
