Glucocorticoid Receptor Polyclonal Antibody
| 规格： | / 60μL / 120μL / 200μL |
| 价格： | / ￥1380 / ￥2220 / ￥3300 |
货号：E-AB-70157
宿主: Rabbit
反应性: H,M,R
应用: WB,IHC
Overview
| Synonyms | GCCR,GCR,GCR,GCRST,glucocorticoid nuclear receptor variant 1,Glucocorticoid receptor,GR,GRL,Grl1,nr3c1,Nuclear receptor subfamily 3 group C member 1,nuclear receptor subfamily 3,group C,member 1 (glucocorticoid receptor),Glucocorticoid Receptor抗体 |
| Swissprot | P04150,P06536,P06537 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant proteincorresponding to Mouse Glucocorticoid receptor |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:1000;IHC,,1:500-1:1000; |
| Concentration | 1.3 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. Nucleus. Cytoplasmic in the absence of ligand, nuclear after ligand-binding and Nucleus. Localized largely in the nucleus. |
| Tissue specificity | Widely expressed including bone, stomach, lung, liver, colon, breast, ovary, pancreas and kidney. In the heart, detected in left and right atria, left and right ventricles, aorta, apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart. Isoform Beta: Widely expressed including brain, bone marrow, thymus, spleen, liver, kidney, pancreas, lung, fat, skeletal muscle, heart, placenta and blood leukocytes. Isoform Alpha-2: Expressed at low level.Highest expression level in endothelial cell. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
| Background | This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. |
Images
Western Blot analysis of various samples using Glucocorticoid Receptor Polyclonal Antibody at dilution of 1:1000.
Immunohistochemistry analysis of paraffin-embedded mouse liver using Glucocorticoid Receptor Polyclonal Antibody at dilution of 1:1000.
Immunohistochemistry analysis of paraffin-embedded rat spleen using Glucocorticoid Receptor Polyclonal Antibody at dilution of 1:1000.
