GLUT-4 Polyclonal Antibody
| 规格： | / 60μL / 120μL / 200μL |
| 价格： | / ￥1380 / ￥2220 / ￥3300 |
货号：E-AB-70104
宿主: Rabbit
反应性: M,R
应用: IHC
Overview
| Synonyms | insulin-responsive,Glucose transporter GLUT 4,Glucose transporter type 4,Glucose transporter type 4 insulin responsive,GLUT 4,GLUT-4,GLUT4,GTR4,Insulin responsive glucose transporter type 4,kug,SLC 2A4,SLC2A4,solute carrier family 2 (facilitated glucose transporter) member 4,Solute carrier family 2 member 4,Solute carrier family 2,facilitated glucose transporter member 4,GLUT-4抗体 |
| Swissprot | P14142,P19357 |
| Source | Rabbit |
| Reactivity | Mouse,Rat |
| Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse GLUT4 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:300-1:1000 |
| Concentration | 1.4 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cell membrane. Endomembrane system. Cytoplasm, perinuclear region. Localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized. The dileucine internalization motif is critical for intracellular sequestration. |
| Tissue specificity | Expressed in skeletal and cardiac muscles. Expressed in brown and white adipose tissues.Highest expression level in skeletal muscle tissue. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
| Background | This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM). |
