GMFG Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-10913
宿主: Rabbit
反应性: H,M,R
应用: WB,IHC
Overview
| Synonyms | Glia maturation factor gamma,Glia maturation factor,gamma,GMF GAMMA,GMF-gamma,Gmfg,GMFG,MGC126867,GMFG抗体 |
| Swissprot | O60234 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant protein of human GMFG |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:2000;IHC,,1:50-1:200; |
| Concentration | 0.3 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Extracellular region or secreted,extracellular region,Other locations:ficolin-1-rich granule lumen,secretory granule lumen |
| Tissue specificity | Expressed predominantly in lung, heart and placenta. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | Glia maturation factor, gamma, also known as GMFG, is a 142 amino acid protein that belongs to the GMF subfamily of the larger actin-binding protein ADF family. GMF-gamma is expressed predominantly in lung, heart and placenta. GMF-gamma is considered a candidate regulatory growth factor protein, mediating both paracrine and autocrine cell-cell interactions. GMF-gamma is phosphorylated at N-terminal serine, and its phosphorylation is enhanced by coexpression of dominant active Rac 1 and Cdc42. GMF-gamma expression is significantly increased in a cardiac ischemia/reperfusion model where inflammation and angiogenesis take place actively. As a regulator of actin-based cellular functions, GMF-gamma may provide a novel approach to modulate the pathophysiology of cardiovascular diseases. GMF-gamma is primarily found in proliferative and differentiative organs. |
Images
Western Blot analysis of Mouse heart and Human fetal brain tissue using GMFG Polyclonal Antibody at dilution of 1:1142
Immunohistochemistry of paraffin-embedded Human cervical cancer using GMFG Polyclonal Antibody at dilution of 1:50
Immunohistochemistry of paraffin-embedded Human colon cancer using GMFG Polyclonal Antibody at dilution of 1:50
