GNRHR Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-12492
宿主: Rabbit
反应性: H,M
应用: WB
Overview
| Synonyms | GnRH receptor,GnRH-R,GNRHR,GNRHR,GNRHR1,Gonadotropin releasing hormone receptor,gonadotropin-releasing hormone (type 1) receptor 1,Gonadotropin-releasing hormone receptor,GRHR,HH7,leutinizing-releasing hormone receptor,lh-rh,LHRHR,LRHR,luliberin receptor,luteinizing hormone releasing hormone receptor,type I GnRH receptor,GNRHR抗体 |
| Swissprot | P30968 |
| Source | Rabbit |
| Reactivity | Human,Mouse |
| Immunogen | Synthetic peptide of human GNRHR |
| Application | WB(Detection kit: E-IR-R304) |
| Recommended dilution | WB,,1:500-1:2000; |
| Concentration | 0.3 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Plasma Membrane,integral component of Plasma Membrane,Other locations:membrane |
| Tissue specificity | Pituitary, ovary, testis, breast and prostate but not in liver and spleen. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene. |
