GREM1 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-14111
宿主: Rabbit
反应性: H,M,R
应用: WB
Overview
| Synonyms | BMP antagonist 1,Cell proliferation inducing gene 2 protein,Cell proliferation-inducing gene 2 protein,CKTSF1B1,colorectal adenoma and carcinoma 1,Cysteine knot superfamily 1,Cysteine knot superfamily 1,BMP antagonist 1,Cysteine knot superfamily BMP antagonist 1,DAN domain family member 2,DAND2,Down regulated in Mos-transformed cells protein,Down-regulated in Mos-transformed cells protein,DRM,grem1,GREM1,Gremlin 1 homolog,cysteine knot superfamily,Gremlin 1 like protein,Gremlin 1,cysteine knot superfamily,homolog,GREMLIN,Gremlin-1,Gremlin1,IHG-2,IHG2,Increased in high glucose 2,Increased in high glucose protein 2,PIG2,Proliferation inducing gene 2,proliferation inducing gene 2 protein,GREM1抗体 |
| Swissprot | O60565 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant protein of human GREM1 |
| Application | WB(Detection kit: E-IR-R304) |
| Recommended dilution | WB,,1:500-1:2000; |
| Concentration | 0.3 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Secreted. |
| Tissue specificity | Highly expressed in small intestine, fetal brain and colon. Expression is restricted to intestinal subepithelial myofibroblasts (ISEMFs) at the crypt base. In subjects with HMPS1, by contrast, GREM1 is expressed, not only in basal ISEMFs, but also at very high levels in epithelial cells (predominantly colonocytes), with expression extending most of the way up the sides of the crypt. Weakly expressed in brain, ovary, prostate, pancreas and skeletal muscle. In brain found in the region localized around the internal capsule in the large subcortical nuclei, including caudate, putamen, substantia nigra, thalamus and subthalamus. Predominantly expressed in normal cells including neurons, astrocytes and fibroblasts. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
