HAND1 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-19541
宿主: Rabbit
反应性: H,M,R
应用: WB,IHC
Overview
| Synonyms | autonomic nervous system and neural crest derivatives-expressed protein 1,Basic helix loop helix transcription factor HAND1,bHLHa27,Class A basic helix-loop-helix protein 27,eHAND,Extraembryonic tissues,Extraembryonic tissues heart autonomic nervous system and neural crest derivatives expressed protein 1,HAND 1,HAND1,HAND1,Heart and neural crest derivatives expressed 1,Heart and neural crest derivatives expressed protein 1,heart,Heart- and neural crest derivatives-expressed protein 1,Hxt,Thing 1,Thing1 ,Thing1,HAND1抗体 |
| Swissprot | O96004 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic peptide of human HAND1 |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:2000;IHC,,1:20-1:100; |
| Concentration | 0.9mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Nucleus>nucleoplasm. Nucleus>nucleolus. Interaction with MDFIC sequesters it into the nucleolus, preventing the transcription factor activity. Phosphorylation by PLK4 disrupts the interaction with MDFIC and releases it from the nucleolus, leading to transcription factor activity. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation. |
Images
Western blot analysis of Human fetal brain tissue lysate using HAND1 Polyclonal Antibody at dilution of 1:400
Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using HAND1 Polyclonal Antibody at dilution of 1:30(×200)
Immunohistochemistry of paraffin-embedded Human brain tissue using HAND1 Polyclonal Antibody at dilution of 1:30(×200)
