HLA-DMB Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-52583
宿主: Rabbit
反应性: H
应用: WB,IHC
Overview
| Synonyms | class II antigen HLA-DM beta chain,class II histocompatibility antigen,Class II histocompatibility antigen M beta chain,D6S221E,DMB,HLA class II histocompatibility antigen DM beta chain,HLA-DM histocompatibility type,beta chain,M beta chain,Major histocompatibility complex class II DM beta,MHC class II antigen DMB,MHC class II antigen HLA DM beta chain,MHC class II HLA DMB,OTTHUMP00000029257,Really interesting new gene 7 protein,RING 7,RING7,HLA-DMB抗体 |
| Swissprot | P28068 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Fusion protein of human HLA-DMB |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:2000;IHC,,1:30-1:150; |
| Concentration | 1.38mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Late endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Localizes to late endocytic compartment. Associates with lysosome membranes. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | HLA-DMB (Major Histocompatibility Complex, Class II, DM Beta) is a Protein Coding gene. Diseases associated with HLA-DMB include Red-Green Color Blindness and Red Color Blindness. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and CTLA4 Signaling. GO annotations related to this gene include MHC class II protein complex binding. An important paralog of this gene is ENSG00000248993.HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. |
