HLA-DRB4 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-52725
宿主: Rabbit
反应性: H
应用: WB
Overview
| Synonyms | DR 4,DR beta 4 chain,DR4,DRB1 transplantation antigen ,DRB4,DRB4,HLA class II histocompatibility antigen,HLA class II histocompatibility antigen DR beta 4 chain ,HLA-DRB4,Human leucocyte antigen DRB4 ,Leukocyte antigen ,Major histocompatibility complex class II DR beta 4 ,MHC class II antigen DRB4,MHC class II antigen HLA DR beta ,MHC class2 antigen ,MHC HLA DR-beta chain,HLA-DRB4抗体 |
| Swissprot | P13762 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Fusion protein of human HLA-DRB4 |
| Application | WB(Detection kit: E-IR-R304) |
| Recommended dilution | WB,,1:500-1:2000; |
| Concentration | 0.84mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cell membrane. Endoplasmic reticulum membrane. Golgi apparatus>trans-Golgi network membrane. Endosome membrane. Lysosome membrane. Late endosome membrane. The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | HLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB4 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. |
