HO1 PoLycLonaL Antibody
| 规格： | / 25ug / 100ug |
| 价格： | / ￥610 / ￥1640 |
货号：D-AB-10377L
货期：咨询
宿主: Rabbit
反应性: H,M
应用: WB,IHC
Overview
| Synonyms | Heme oxygenase 1;HO-1;HMOX1;HO;HO1;EC:1.14.14.18 |
| Swissprot | P09601 |
| Source | Rabbit |
| Reactivity | Human;Mouse |
| Immunogen | Recombinant Human HO1 Protein expressed by E.coLi |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:1000;IHC,,1:500-1:1000 |
| Concentration | 1mg/mL |
| Clonality | Polyclonal |
Properties
| Isotype | IgG |
| Purification | Antigen Affinity Purification |
| Conjugation | Unconjugated |
| Storage instructions | Storeat-20℃ Valid for12months.Avoid freeze/thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4 |
| Background | Heme Oxygenase (HO),also known as HMOX,is the rate limiting enzyme in the breakdown of heme into Biliverdin,CO,and iron. There are two major isoforms of this enzyme,HO-1 and HO-2. Both have similar enzymatic activity,however,HO-1 is rapidly inducible,while HO-2 is constitutively expressed. Inducers of HO-1 include cell stressors such as oxidative stress,infection,hypoxia,and cytotoxic agents. The reaction products generated by HO-1 activity are biologically active,and the enzyme has a broad range of putative roles. For instance,Biliverdin is an antioxidant with cytoprotective and anti-inflammatory properties,and CO has the potential to suppress inflammation and apoptosis. Because of these activities,HO-1 has received much attention as a therapeutic target for a range of pathological processes. |
