HUS1 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-52729
宿主: Rabbit
反应性: H,M
应用: IHC
Overview
| Synonyms | Checkpoint protein HUS1,hHUS1,HUS1 (S. pombe) checkpoint homolog,Hus1,HUS1 checkpoint homolog (S. pombe),HUS1 Checkpoint Protein,HUS1 protein,HUS1+ - like protein,HUS1,Hydroxyurea-sensitive 1, S. pombe, homolog of,HUS1抗体 |
| Swissprot | O60921 |
| Source | Rabbit |
| Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human HUS1 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:40-1:200 |
| Concentration | 0.78mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Nucleus. Cytoplasm. In discrete nuclear foci upon DNA damage. According to PubMed:14500360, localized also in the cytoplasm. DNA damage induces its nuclear translocation. Shuttles between the nucleus and the cytoplasm. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage.This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1.In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin.The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event.Alternative splicing results in multiple transcript variants. |
