HUWE1 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-19540
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
| Synonyms | ARF binding protein 1,ARF BP1,ARF-binding protein 1,ARF-BP1,BJ-HCC-24 tumor antigen,E3 ubiquitin protein ligase HUWE1,E3 ubiquitin-protein ligase HUWE1,HECT,HECT domain protein LASU1,HECT UBA and WWE domain containing protein 1,HectH9,Homologous to E6AP carboxyl terminus homologous protein 9,Huwe1,HUWE1,Ib772,Large structure of UREB1,LASU1,Mcl 1 ubiquitin ligase E3,Mcl-1 ubiquitin ligase E3,Mule,UBA and WWE domain-containing protein 1,Upstream regulatory element-binding protein 1,URE-B1,URE-binding protein 1,UREB1,HUWE1抗体 |
| Swissprot | Q7Z6Z7 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic peptide of human HUWE1 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:10-1:50 |
| Concentration | 0.8mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. Nucleus. Mainly expressed in the cytoplasm of most tissues, except in the nucleus of spermatogonia, primary spermatocytes and neuronal cells (By similarity). Predominantly cytosolic or perinuclear in some colorectal carcinoma cells. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related)). This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with Turner type X-linked syndromic mental retardation. |
