ICAM-1/CD54 Monoclonal Antibody(Detector)
| 规格： | / 25μg / 100μg |
| 价格： | / ￥800 / ￥2100 |
货号：AN001450P
货期：咨询
宿主: Mouse
反应性: R
应用: ELISA Detector
Overview
| Synonyms | InterceLLuLar adhesion moLecuLe 1;ICAM-1;CD54;Icam1;Icam-1 |
| Swissprot | Q00238 |
| Source | Mouse |
| Reactivity | Rat |
| Immunogen | Recombinant Rat ICAM-1/CD54 Protein expressed by Mammalian |
| Application | ELISA Detector |
| Recommended dilution | ELISA Detector,,0.1-0.4 μg/mL |
| Concentration | 1mg/mL |
| Clonality | Monoclonal |
Properties
| Clone No | 9E10 |
|---|---|
| Isotype | IgG1 |
| Purification | Protein A/G Purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at 4°C Valid for 1 month or -20°C Valid for 12 months,Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions. |
| Storage buffer | Sterile PBS,pH 7.4 |
| Background | ICAM-1 (intercellular adhesion molecule-1),also known as CD54,is a transmembrane protein that is upregulated on endothelial and epithelial cells at sites of inflammation. It mediates the vascular adhesion and paracellular migration of leukocytes expressing activated lFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). It also binds several non-integrin ligands including CD43/Sialophorin,Fibrinogen,Hyaluronan,rhinoviruses,and Plasmodium falciparum-infected erythrocytes. Soluble ICAM-1 promotes angiogenesis and serves an indicator of vascular endothelial cell activation or damage. Elevated levels of soluble ICAM-1 are associated with cardiovascular disease,type 2 diabetes,organ transplant dysfunction,oxidant stress,increased abdominal fat mass,hypertension,liver disease,certain malignancies,and cerebral malaria. |
