IFITM3 Polyclonal Antibody
| 规格： | / 50μL / 100μL |
| 价格： | / ￥1010 / ￥1640 |
货号：D-AB-10162L
货期：咨询
宿主: Rabbit
反应性: H,M,R
应用: WB,IHC,IF
Overview
| Synonyms | 1 8U,Fragilis,IFITM3,IFM3,Interferon induced transmembrane protein 3 (1 8U),Interferon Induced Transmembrane Protein 3,Interferon inducible,Interferon inducible protein 1 8U,Interferon Inducible Protein 15,Interferon Inducible Protein Homolog,Interferon-induced transmembrane protein 3,Interferon-inducible protein 1-8U,IP15 |
| Swissprot | P26376 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant Rat IFITM3 protein expressed by E.coli |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213),IF |
| Recommended dilution | WB,,1:1000-1:2000;IHC,,1:50-1:200;IF,,1:100-1:400; |
| Concentration | 1mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cell membrane.Cytoplasm |
| Tissue specificity | Highest expression level in lung |
| Isotype | IgG |
| Purification | Antigen Affinity Purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,1% protective protein and 50% glycerol,pH7.4 |
| Background | IFITM3,also named as interferon-inducible protein 1-8U,belongs to the CD225 family. It is IFN-induced antiviral protein that mediates cellular innate immunity to at least three major human pathogens,namely influenza A H1N1 virus,West Nile virus (WNV),and dengue virus,by inhibiting the early steps of replication. IFITM3 is identified as interferon-induced cellular proteins that restrict infections by retroviruses and filoviruses and of influenza virus and flaviviruses,respectively. IFITM3,the most potent antiviral IFITM,was found to inhibit an uncharacterized early infectious event after VSV endocytosis,but before primary transcription of its viral genome. IFITM proteins are viral restriction factors that can inhibit infection mediated by the influenza A virus (IAV) hemagglutinin (HA) protein. They differentially restrict the entry of a broad range of enveloped viruses,and modulate cellular tropism independently of viral receptor expression. This antibody recognizes both IFITM2 and IFITM3. |
Images
Western blot with IFITM3 Polyclonal antibody at dilution of 1:2000.lane 1:Hela whole cell lysate, lane 2:293 T whole cell lysate, lane 3:Mouse Liver, lane 4:Mouse Heart,lane 5:Rat Liver
Immunohistochemistry of paraffin-embedded Rat kidney using IFITM3 Polyclonal Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded Mouse lung using IFITM3 Polyclonal Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded Human lung cancer using IFITM3 Polyclonal Antibody at dilution of 1:200
Immunofluorescence analysis of Hela cells using IFITM3 Polyclonal Antibody at dilution of 1:100
