IFN-alpha 1 Monoclonal Antibody(Capture)
| 规格： | / 25μg / 100μg |
| 价格： | / ￥800 / ￥2100 |
货号：AN002640P
货期：咨询
宿主: Rat
反应性: M
应用: ELISA Capture
Overview
| Synonyms | Ifna;IL-1ra Homolog;IFN-α;IL-1F;IL-1L;IL-1HY;IL-1RP;IFN-alpha;FIL1 delta;IFN-alpha-1;IFN-α1;IL-1 delta;IL-1F5;IL-1HY1;IL-1L1;IL-1ra Homolog 1;IL-1RP3;Ifna1 |
| Swissprot | P01572 |
| Source | Rat |
| Reactivity | Mouse |
| Immunogen | Recombinant Mouse IFN-alpha 1 protein expressed by Mammalian |
| Application | ELISA Capture |
| Recommended dilution | ELISA Capture,,2-8 μg/mL |
| Concentration | 1mg/mL |
| Clonality | Monoclonal |
Properties
| Clone No | 7B2 |
|---|---|
| Isotype | IgG2a |
| Purification | Protein A/G Purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at 4°C Valid for 1 month or -20°C Valid for 12 months,Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions. |
| Storage buffer | Sterile PBS,pH 7.4 |
| Background | The interferons (IFN) are a family of cytokines with potent antiviral, antiproliferative and immunomodulatory properties, and classified based on their binding specificity to cell surface receptors. The type I IFN bind to the interferon alpha receptor (IFNAR), which consists of two subunits: IFNAR1 ( alpha -subunit) and IFNAR2 ( beta -subunit). This binding contributes to TNF-alpha induced signaling. Both the human and mouse genome code for more than a dozen closely related IFNa subtypes and the varous IFN a share about 80% sequence homology among them. Interferon-alpha 1 (IFNA1) is a secreted, approximately 19 kDa member of the type I interferon family of molecules. Mature mouse IFN-alpha 1 shares 63% and 82% amino acid sequence identity with human and rat IFN-alpha 1, respectively. Low level IFN-alpha is detected under physiological conditions, and the production of IFNs is markedly enhanced during virus infection. Although originally discovered by its capability to fight virus replication, IFN-alpha functions as a prototypic tumor suppressor that represses the clinical tumorigenic phenotype in some malignancies. |
