IFT57 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-19035
宿主: Rabbit
反应性: H,M
应用: IHC
Overview
| Synonyms | CDNA FLJ10147 fis clone HEMBA1003369,Dermal papilla derived protein 8,Dermal papilla-derived protein 8,DERP 8,DERP8,Esrrbl 1,Esrrbl1,ESRRBL1 protein,Estrogen related receptor beta like 1,Estrogen related receptor beta like protein 1,Estrogen-related receptor beta-like protein 1,FLJ10147,Hip1 Interacting protein,HIP1 interacting protein HIPPI,Hip1 protein interactor,HIP1-interacting protein,HIPPI,Huntingtin interacting protein 1 interacting protein,Huntingtin interacting protein 1 protein interactor,IFT 57,ift57,IFT57,Intraflagellar transport 57 homolog (Chlamydomonas),Intraflagellar transport 57 homolog,Intraflagellar transport protein 57 homolog,MHS4R2,Vestrogen related receptor beta like 1,IFT57抗体 |
| Swissprot | Q9NWB7 |
| Source | Rabbit |
| Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human IFT57 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:300 |
| Concentration | 1.5mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm>cytoskeleton>cilium basal body. Concentrates within the inner segment of cilia. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear. |
