IL10 Polyclonal Antibody
| 规格： | / 60μL / 120μL / 200μL |
| 价格： | / ￥1380 / ￥2220 / ￥3300 |
货号：E-AB-70235
宿主: Rabbit
反应性: M,R
应用: IHC,IF
Overview
| Synonyms | CSIF,Cytokine synthesis inhibitory factor,GVHDS,IL 10,IL-10,IL10,IL10,IL10A,Interleukin 10,Interleukin-10,MGC126450,MGC126451,T-cell growth inhibitory factor,TGIF,IL10抗体 |
| Swissprot | P18893,P29456 |
| Source | Rabbit |
| Reactivity | Mouse,Rat |
| Immunogen | KLH conjugated Synthetic peptide corresponding to IL-10 |
| Application | IHC(Detection kit: E-IR-R213),IF |
| Recommended dilution | IHC,,1:200-1:1000;IF,,1:200-1:1000; |
| Concentration | 150 μg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Secreted. |
| Tissue specificity | Highest expression level in bone marrow macrophage |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
| Background | Interleukin (IL)-10 is an anti-inflammatory cytokine, produced by T helper (Th) cells, macrophages, monocytes, and B cells, that plays a crucial role in preventing inflammatory and autoimmune pathologies. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway. IL-10, along with its receptors, describes an important role in pathogenesis of various diseases, including infectious, inflammatory, autoimmune diseases. IL-10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. |
