IL10RA Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-13869
宿主: Rabbit
反应性: H
应用: IHC
Overview
| Synonyms | CD210,CDw210a,CDw210a antigen,HIL 10R,HIL10R,I10R1,IL 10R 1,IL 10R A,IL 10R,IL 10R1,IL-10 receptor subunit alpha,IL-10R subunit 1,IL-10R subunit alpha,IL-10R1,IL-10RA,IL10R,IL10R1,IL10RA,Interleukin 10 receptor alpha,Interleukin 10 receptor alpha chain,Interleukin-10 receptor subunit 1,Interleukin-10 receptor subunit alpha,IL10RA抗体 |
| Swissprot | Q13651 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Recombinant protein of human IL10RA |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:200 |
| Concentration | 0.6 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Membrane. |
| Tissue specificity | Spleen, thymus, and PBMC. Weak expression in pancreas, skeletal muscle, brain, heart, and kidney. Placenta, lung, and liver showed intermediate levels. Monocytes, B-cells, large granular lymphocytes, and T-cells express high levels. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. |
