IL12B Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-19816
宿主: Rabbit
反应性: H
应用: IHC
Overview
| Synonyms | CLMF,CLMF p40,CLMF2,Cytotoxic lymphocyte maturation factor 40 kDa subunit,IL 12B,IL-12 subunit p40,IL-12B,IL12 p40,IL12B,IL12B,IMD28,IMD29,Interleukin 12 beta chain,Interleukin 12 p40,Interleukin-12 subunit beta,NK cell stimulatory factor chain 2,NKSF,NKSF2,IL12B抗体 |
| Swissprot | P29460 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Synthetic peptide of human IL12B |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:40-1:200 |
| Concentration | 1.32mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Secreted. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | Interleukin-12 (IL-12),is a cytokine that is secreted by activated phagocytes and dendritic cells and that induces interferon-γproduction by natural-killer and T lymphocytes. IL-12 is a 75 kDa heterodimer composed of a 35 kDa subunit (IL-12A p35) and a 40 kDa subunit (IL-12B p40) that is secreted by a wide variety of antigen presenting cells (APCs),including phagocytes,B cells and Langerhans cells. IL-12B has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of IL-12B was observed in the central nervous system of patients with multiple sclerosis (MS),suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of IL-12B has been reported to be associated with the severity of atopic and non-atopic asthma in children. |
