IL6ST Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-52510
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
| Synonyms | CD130,CD130 antigen,CDw130,gp130,GP130 RAPS,IL 6R beta,IL-6 receptor subunit beta,IL-6R subunit beta,IL-6R-beta,IL-6RB,IL6 ST,IL6RB,IL6ST,Interleukin 6 receptor subunit beta,Interleukin receptor beta chain,Interleukin-6 receptor subunit beta,Interleukin-6 signal transducer,Membrane glycoprotein 130,Membrane glycoprotein gp130,Oncostatin M receptor,Oncostatin M receptor alpha subunit,Oncostatin-M receptor subunit alpha,IL6ST抗体 |
| Swissprot | P40189 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Fusion protein of human IL6ST |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:30-1:150 |
| Concentration | 0.7mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Secreted and Cell membrane. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. |
