IL-6R alpha Polyclonal Antibody(Capture/Detector)
| 规格： | / 25μg / 100μg |
| 价格： | / ￥800 / ￥2100 |
货号：AN000410P
货期：咨询
宿主: Goat
反应性: M
应用: ELISA Capture/Detector
Overview
| Synonyms | InterLeukin-6 receptor subunit aLpha;IL-6 receptor subunit aLpha;IL-6R subunit aLpha;IL-6R-aLpha;IL-6RA;IL-6R 1 |
| Swissprot | P22272 |
| Source | Goat |
| Reactivity | Mouse |
| Immunogen | Recombinant Mouse IL-6R alpha ra Protein expressed by Mammalian |
| Application | ELISA Capture/Detector |
| Recommended dilution | ELISA Capture,,2-8 μg/mL;ELISA Detector,,0.1-0.4 μg/mL |
| Concentration | 1mg/mL |
| Clonality | Polyclonal |
Properties
| Isotype | IgG |
| Purification | Antigen Affinity Purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at 4°C Valid for 1 month or -20°C Valid for 12 months,Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions. |
| Storage buffer | Sterile PBS,pH 7.4 |
| Background | Part of the receptor for interleukin 6. Binds to Il6 with low affinity,but does not transduce a signal. Signal activation necessitate an association with Il6ST. Activation leads to the regulation of the immune response,acute-phase reactions and hematopoiesis. The interaction with membrane-bound Il6R and Il6ST stimulates 'classic signaling',the restricted expression of the Il6R limits classic Il6 signaling to only a few tissues such as the liver and some cells of the immune system. Whereas the binding of Il6 and soluble Il6R to Il6ST stimulates 'trans-signaling'. Alternatively,'cluster signaling' occurs when membrane-bound Il6:Il6R complexes on transmitter cells activate Il6ST receptors on neighboring receiver cells. |
