ILF3 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-18909
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
| Synonyms | CBTF,Double stranded RNA binding protein 76,Double-stranded RNA-binding protein 76,DRBF,DRBP76,ILF3,ILF3,Interleukin enhancer binding factor 3,Interleukin enhancer-binding factor 3,M phase phosphoprotein 4,M-phase phosphoprotein 4,MPHOSPH4,MPP4,NF AT 90,NF-AT-90,NF110,NF90,NFAR,Nuclear factor associated with dsRNA,Nuclear factor of activated T cells 90 kDa,Nuclear factor of activated T-cells 90 kDa,TCP80,Translational control protein 80,ILF3抗体 |
| Swissprot | Q12906 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Fusion protein of human ILF3 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:300 |
| Concentration | 1.08mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Nucleus>nucleolus. Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein (NF90, ILF3) forms a heterodimer with a 45 kDa transcription factor (NF45, ILF2) required for T-cell expression of interleukin 2. This complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
